Figure 8

The effect of RS504393 on IAMNT-induced heat hyperalgesia. Intracisternal injection of RS504393, given at 3 days (A) or 10 days (B) after IAMNT, significantly reduced heat hyperalgesia on the ipsilateral facial skin. However, 10 μg RS50439310 did not affect the HWL in naive animals (C). * P < 0.05, ** P < 0.01, 1 μg RS504393 versus vehicle; + P < 0.05, ++ P < 0.01, +++ P < 0.001, 10 μg RS504393 versus vehicle. BL, baseline.