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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Treatment with MOG-DNA vaccines induces CD4+CD25+FoxP3+ regulatory T cells and up-regulates genes with neuroprotective functions in experimental autoimmune encephalomyelitis

Figure 2

MOG-DNA therapy decreased neuropathology associated with EAE. Representative histopathologies of the spinal cord 32 days post-EAE induction in mice previously treated either with MOG-DNA or plasmid control according to a prophylactic protocol. Spinal cords were stained to evaluate cell infiltration (H&E; A), demyelination (KB; B), T cell infiltration (CD3; C), microglia/macrophage activation (LEA; D), reactive astrogliosis (GFAP; E), and axonal damage (SMI-32; F). Bar graphs represent mean number of cells/mm2 (SEM) observed in one representative experiment with five mice per group.

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