Treatment with MOG-DNA vaccines induces CD4+CD25+FoxP3+ regulatory T cells and up-regulates genes with neuroprotective functions in experimental autoimmune encephalomyelitis

Table 1 Top-scoring gene ontology categories down-regulated in mice vaccinated with MOG-encoding DNA

GO ID	Category	MGSA^a	Enrichment^b	Expression^c
GO:0006954	Inflammatory response	0.935	4.1	Downregulated
GO:0002376	Immune system process	0.758	3.2	Downregulated
GO:0030133	Transport vesicle	0.719	3.9	Downregulated
GO:0000323	Lytic vacuole	0.609	4.3	Downregulated
GO:0015914	Phospholipid transport	0.511	4.1	Downregulated

GO-oriented analysis with differentially expressed genes obtained with microarrays from brain and spinal cord tissue was conducted in order to classify biologically related genes. Ontologizer 2.0 software was used for GO term enrichment analysis.
^aMGSA: score obtained using a model-based gene set analysis. Only categories with a score >0.5 are represented.
^bEnrichment values indicate how many times genes from the corresponding GO categories are overrepresented in the list of differentially expressed genes compared to the list of random genes.
^cExpression: refers to the direction in gene expression observed in MOG-DNA treated mice (n = 5) versus plasmid control mice (n = 5). GO ID: GO identification.

ISSN: 1742-2094