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Table 5 Time to relapse if disease started either with ON or MY.

From: Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients

  Time (median, range, N) p-level
1st → 2nd attack   
   All patients 8.5 months (1-216; N = 138) n.a.
Patients meeting Wingerchuk's 2006 criteria 9 months (1-216; N = 97) n.a.
   Seropositives 9 months (1-201; N = 113) n.s.
   Seronegatives 5 months (1-216; N = 25)  
   ON at onset 17 months (1-208; N = 67) p < 0.002§
   MY at onset 6 months (1-216; N = 61)  
   MY+ON at onset 3.5 months (1-8; N = 10)  
   Brainstem encephalitis at onset 5 months (2-20; N = 4)  
1st ON → 2nd ON 24 months (1-381; 79) p < 0.0001§
1st MY → 2nd MY 7 months (0-296; 121)  
1st ON → 1st MY 14 months (0-349; 85) p < 0.0005§
1st MY → 1st ON 3 months (0-217; 41)  
  1. Irrespective of whether the first event was ON or MY or simultaneous ON and MY. §Mann Whitney U test. N = number of patients (not all data were available from all patients); n.a. = not applicable; n.s. = not significant.