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Table 6 Optic neuritis, comparison of clinical features according to the patient's AQP4-Ab serostatus.

From: Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients

 

Seropositive

Seronegative

p-level

Annualized ON relapse rate†

   

   All patients with a history of ON

0.38 (0.04-2.25; N = 83)

0.36 (0.08-3; N = 21)

n.s.§

Patients meeting Wingerchuk's 2006

criteria

0.37 (0.04-2.25; N = 80)

0.25 (0.08-3; N = 19)

n.s.§

Bilateral ON ever

   

   All patients with a history of ON

25/92 (27.2%)

15/29 (51.7%)

p < 0.023‡

Patients meeting Wingerchuk's 2006

criteria

23/87 (26.4%)

14/27 (51.9%)

p < 0.019‡

Bilateral ON at first ON attack*

   

   All patients with a history of ON

12/85 (14.1%)

11/28 (39.3%)

p < 0.007‡

Patients meeting Wingerchuk's 2006

criteria

12/81 (14.8%)

10/26 (38.5%)

p < 0.023‡

ON attacks with VA ≤ 0.1

   

   All patients with a history of ON

83/123 (67.5%)

13/35 (37.1%)

p < 0.002‡

Patients meeting Wingerchuk's 2006

Criteria

74/112 (66.1%)

12/33 (36.4%)

p < 0.005‡

Attacks with complete recovery

   

   All patients with a history of ON

68/205 (33.2%)

15/51 (29.4%)

n.s.‡

Patients meeting Wingerchuk's 2006

Criteria

64/190 (33.7%)

13/42 (31%)

n.s.‡

  1. †Only patients with a disease duration > = 12 months were considered. *Irrespective of whether at disease onset or not. ‡Fisher's exact test (2-tailed). §Mann Whitney U test. ON = optic neuritis; N = number of patients (not all data were available from all patients); n.s. = not significant; VA = visual acuity.