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Table 6 Optic neuritis, comparison of clinical features according to the patient's AQP4-Ab serostatus.

From: Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients

  Seropositive Seronegative p-level
Annualized ON relapse rate    
   All patients with a history of ON 0.38 (0.04-2.25; N = 83) 0.36 (0.08-3; N = 21) n.s.§
Patients meeting Wingerchuk's 2006 criteria 0.37 (0.04-2.25; N = 80) 0.25 (0.08-3; N = 19) n.s.§
Bilateral ON ever    
   All patients with a history of ON 25/92 (27.2%) 15/29 (51.7%) p < 0.023
Patients meeting Wingerchuk's 2006 criteria 23/87 (26.4%) 14/27 (51.9%) p < 0.019
Bilateral ON at first ON attack*    
   All patients with a history of ON 12/85 (14.1%) 11/28 (39.3%) p < 0.007
Patients meeting Wingerchuk's 2006 criteria 12/81 (14.8%) 10/26 (38.5%) p < 0.023
ON attacks with VA ≤ 0.1    
   All patients with a history of ON 83/123 (67.5%) 13/35 (37.1%) p < 0.002
Patients meeting Wingerchuk's 2006 Criteria 74/112 (66.1%) 12/33 (36.4%) p < 0.005
Attacks with complete recovery    
   All patients with a history of ON 68/205 (33.2%) 15/51 (29.4%) n.s.
Patients meeting Wingerchuk's 2006 Criteria 64/190 (33.7%) 13/42 (31%) n.s.
  1. Only patients with a disease duration > = 12 months were considered. *Irrespective of whether at disease onset or not. Fisher's exact test (2-tailed). §Mann Whitney U test. ON = optic neuritis; N = number of patients (not all data were available from all patients); n.s. = not significant; VA = visual acuity.