Figure 6
From: The neuroprotective effects of milk fat globule-EGF factor 8 against oligomeric amyloid β toxicity
Model of the neuroprotective role of MFG-E8 against Aβ toxicity. MFG-E8 is secreted from microglia in response to soluble factors (for example, FKN) produced by degenerated neurons. MFG-E8 enhances Aβ phagocytosis by microglia through CD47 expression. MFG-E8 also directly increases the nuclear translocation of the transcriptional factor Nrf2, which induces expression of the antioxidant enzyme HO-1. Therefore, MFG-E8 is a potent downstream molecule of sFKN and is an intrinsic neuroprotectant for damaged yet surviving neurons.