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Table 10 Changes (nanomole percent by weight composition) in rat plasma phosphatidylethanolamine molecular species following intraventricular infusion with propionic acid (PPA) and phosphate buffered saline (PBS)

From: The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders

Molecular weight

Molecular species

Plasmalogen or diacyl species

PBS

PPA

702

P34:1

p16:0/18:1

4.59 ± 0.43

3.51 ± 0.53

716

D34:2

16:0/18:2

4.42 ± 0.13

4.41 ± 0.66

732

P36:0

p18:0/18:0

4.39 ± 0.19

3.11 ± 0.41*

746

D36:1

18:0/18:1

4.55 ± 0.44

3.38 ± 0.49*

730

P36:1

p18:0/18:1

5.76 ± 0.56

3.57 ± 0.50 *

744

D36:2

18:0/18:2

5.20 ± 0.58

4.49 ± 0.55

728

P36:2

p18:0/18:2

3.10 ± 1.36

3.19 ± 0.26

726

P36:3

p18:1/18:2

4.28 ± 0.19

3.85 ± 0.36

724

P36:4

p16:0/20:4

4.47 ± 0.42

3.41 ± 0.46*

768

D38:4

18:0/20:4

10.82 ± 0.71

23.60 ± 4.93*

752

P38:4

p18:0/20:4

4.67 ± 0.06

3.70 ± 0.45*

764

D38:6

16:0/22:6

5.35 ± 0.21

7.02 ± 0.56*

748

P38:6

p16:0/22:6

4.87 ± 0.38

3.71 ± 0.64

798

D40:3

18:0/22:3

4.27 ± 0.34

3.92 ± 0.68

796

D40:4

20:0/20:4

4.78 ± 0.29

3.67 ± 0.62

780

P40:4

p18:0/22:4

4.06 ± 0.17

3.41 ± 0.34

794

D40:5

18:0/22:5

4.97 ± 0.35

4.07 ± 0.32

778

P40:5

p18:0/22:5

4.67 ± 0.27

3.76 ± 0.83

792

D40:6

18:0/22:6

5.89 ± 0.62

7.03 ± 1.63

776

P40:6

p18:0/22:6

4.80 ± 0.33

3.54 ± 0.69*

Total%

  

100

100

∑ Saturates

  

4.39 ± 0.19

3.11 ± 0.41*

∑ Monounsat

  

14.92 ± 0.39

10.46 ± 1.46*

∑ Polyunsat

  

80.68 ± 0.43

86.41 ± 1.81*

∑ Plas

  

49.69 ± 0.96

38.37 ± 3.81*

  1. Values (nanomole percent by weight composition) represent means ± standard errors. Means in the same row accompanied by asterisks are significantly different between treatments at LSD = 0.05, n = 12 per treatment group. D represents diacyl species and P represents plasmalogens species, p denotes a sn-1 vinyl ether (plasmalogen) linkage. Monounsat, monounsaturated fatty acids; PBS, phosphate buffered saline solution, plas, plasmalogens; polyunsat, polyunsaturated fatty acids; PPA, propionic acid. Phosphatidylethanolamine molecular species were identified using neutral loss scan of 141 D in ESI positive mode. The lipid components in the table are arranged based on the molecular species composition.