The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders

Table 6 Changes (percent composition) in rat plasma phosphatidylinositol molecular species following intraventricular infusion with propionic acid (PPA) and phosphate buffered saline (PBS)

Molecular weight	Molecular species	Diacyl/species	PBS	PPA
835	D34:1	16:0/18:1	6.71 ± 0.66	9.04 ± 0.39*
859	D36:3	18:1/18:2	6.16 ± 0.29	8.67 ± 0.97*
857	D36:4	16:0/20:4	8.33 ± 1.03	8.70 ± 0.85
887	D38:3	18:0/20:3	8.53 ± 0.63	7.72 ± 0.69
885	D38:4	18:0/20:4	44.00 ± 2.19	32.68 ± 3.6*
883	D38:5	18:1/20:4	6.67 ± 0.56	7.79 ± 0.28
881	D38:6	16:0/22:6	6.17 ± 0.04	7.89 ± 0.50*
913	D40:4	18:0/22:4	6.50 ± 0.60	8.47 ± 0.31*
909	D40:6	18:0/22:6	6.93 ± 0.54	9.04 ± 0.38*
Total%			100	100
∑ Monounsat			6.70 ± 0.66	9.03 ± 1.03
∑ Polyunsat			93.29 ± 0.66	90.96 ± 1.03

Values (nanomole percent by weight composition) represent means ± standard errors. Means in the same row accompanied by asterisks are significantly different between treatments at LSD = 0.05, n = 12 per treatment group. D represents diacyl species. Monounsat, monounsaturated fatty acids; PBS, phosphate buffered saline solution, polyunsat, polyunsaturated fatty acids; PPA, propionic acid. Phosphatidylinositol molecular species were identified using a precursor ion scan of m/z 241 in ESI negative mode. The lipid components in the table are arranged based on the molecular species composition.

ISSN: 1742-2094