The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders

Table 8 Changes (nanomole percent by weight composition) in rat plasma phosphatidylserine molecular species following intraventricular infusion with propionic acid (PPA) and phosphate buffered saline (PBS)

Molecular weight	Molecular species	Diacyl species	PBS	PPA
762	D34:1	16:0/18:1	6.55 ± 0.30	7.94 ± 0.09*
792	D36:0	18:0/18:0	8.12 ± 0.57	7.62 ± 0.24
790	D36:1	18:0/18:1	9.53 ± 0.74	12.13 ± 1.21*
788	D36:2	18:0/18:2	7.81 ± 0.06	8.84 ± 0.63*
818	D38:1	18:0/20:1	7.72 ± 0.24	6.94 ± 0.63
812	D38:4	18:0/20:4	11.55 ± 1.36	11.76 ± 1.65
842	D40:3	18:0/22:3	8.64 ± 0.53	7.37 ± 0.51*
840	D40:4	18:0/22:4	7.81 ± 0.08	7.50 ± 0.35
838	D40:5	18:0/22:5	7.61 ± 0.23	7.69 ± 0.06
836	D40:6	18:0/22:6	16.67 ± 1.34	13.68 ± 0.88*
834	D40:7	18:1/22:6	7.99 ± 0.37	8.53 ± 0.19
Total%			100	100
∑ Saturates			8.12 ± 0.57	7.62 ± 0.24
∑ Monounsat			23.80 ± 1.76	27.02 ± 1.99*
∑ Polyunsat			68.06 ± 0.99	65.34 ± 1.18*

Values (nanomole percent by weight composition) represent means ± standard errors. Means in the same row accompanied by asterisks are significantly different between treatments at LSD = 0.05, n = 12 per treatment group. D represents diacyl species. Monounsat, monounsaturated fatty acids; PBS, phosphate buffered saline solution; polyunsat, polyunsaturated fatty acids; PPA, propionic acid. Phosphatidylserine molecular species were identified using neutral loss scan of 185 D in ESI positive mode. The lipid components in the table are arranged based on the molecular species composition.

ISSN: 1742-2094