Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

Table 1 Summary of patient details and lesion types

MS cases	Age (years)	Type of MS	Gender	PM delay (h)	Disease duration (years)	No. tissue blocks	No. lesions	Preactive lesions	Active lesions	Chronic active lesions	Chronic inactive lesions
1	63	PP	M	7	24	7	3	1	1	1	2
2	56	SP	M	8	21	7	5	2	0	2	0
3	69	ND	F	8	54	6	3	1	0	1	2
4	70	PP	F	7	40	8	3	2	0	1	2
5	78	SP	F	11	30	8	8	0	0	0	0
6	76	PP	F	10	19	7	5	0	0	0	2
7	47	ND	F	4	16	7	3	1	0	3	0
8	41	PP	M	7	14	9	1	8	2	5	0
9	66	ND	F	6	22	12	5	5	11	0	1
10	49	SP	M	8	25	17	5	1	0	11	0
11	55	PP	M	6	32	9	3	0	0	2	4
12	66	PP	M	8	26	14	1	5	0	13	0
13	57	SP	M	8	25	8	2	3	1	1	2
14	61	SP	M	9	41	14	7	2	0	5	1
15	45	SP	M	8	10	6	3	0	0	1	2
16	50	ND	M	10	16	10	4	0	0	1	5
17	44	PP	M	12	13	10	4	2	3	3	2
18	75	PP	M	8	39	8	7	0	0	1	1
19	68	PR	F	11	37	12	10	2	0	1	1
20	44	SP	M	10	22	17	3	9	0	10	0
21	51	PR	M	11	>10	17	5	0	6	4	1
						213	90	44	24	66	28
Controls
1	57		M	6
2	84		F	5
3	72		M	10
4	77		F	8
5	72		F	5
6	64		F	9

PP, primary progressive; SP, secondary progressive; PR, progressive relapsing; ND, MS subtype not determined; F, female; M, male;
PM delay, post-mortem delay

ISSN: 1742-2094