Figure 7From: Delayed expression of cell cycle proteins contributes to astroglial scar formation and chronic inflammation after rat spinal cord contusion Cavity formation is progressive after chronic contusion and is attenuated by CDKs inhibition. SCI-induced lesion volume/cavity formation was measured with GFAP/DAB staining and analyzed by unbiased stereological techniques. (A) Representative images showed lesion cavity at 3 mm rostral to the injury center at 4 weeks (b) and 4 months (c) after SCI. Scale bars = 500 μm. (B) Histological assessment showed that 4 months-SCI rats developed a larger lesion cavity (52.4 ± 5.0% of total volume) than that in 4 weeks-SCI animals (28.4 ± 3.9% of total volume). Notably, a significant reduction in lesion volume was found in rats that received delayed systemic treatment of CR8 at 4 months post-injury (40.8 ± 3.6% of total volume). *p < 0.05 vs. SCI-4 weeks Veh group; # p < 0.05 vs. SCI-4 months Veh group. n = 6 rats/group.Back to article page