Figure 6

Mechanism of granulocyte recruitment at the blood-brain interface during PTX exposure. The present results, together with those from a previous study [17], allow us to propose the following mechanism: 1) PTX induces IL-6 expression in peripheral cells through a receptor that remains to be identified; 2) IL-6 travels in the blood and stimulates CXCL1 expression in endothelial cells by acting transcriptionally; 3) IL-6 also stimulates ICAM1 expression by acting post-transcriptionally and in synergy with a second mediator acting transcriptionally; 4) granulocytes are activated by the binding of CXCL1 to CXCR2 and adhere to the endothelium through interaction between Mac1 and ICAM1.