Figure 6
![Figure 6](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2F1742-2094-9-18/MediaObjects/12974_2011_504_Fig6_HTML.jpg)
Mechanism of granulocyte recruitment at the blood-brain interface during PTX exposure. The present results, together with those from a previous study [17], allow us to propose the following mechanism: 1) PTX induces IL-6 expression in peripheral cells through a receptor that remains to be identified; 2) IL-6 travels in the blood and stimulates CXCL1 expression in endothelial cells by acting transcriptionally; 3) IL-6 also stimulates ICAM1 expression by acting post-transcriptionally and in synergy with a second mediator acting transcriptionally; 4) granulocytes are activated by the binding of CXCL1 to CXCR2 and adhere to the endothelium through interaction between Mac1 and ICAM1.