Representative changes in superoxide anion (O
) production and protein oxidation in the bilateral CA3 subfield of the hippocampus 24 h after microinjection of kainic acid (KA) (0.5 nmol) or PBS into the left hippocampal CA3 subfield in animals that received pretreatment with application into the bilateral CA3 subfield of 3% dimethyl sulfoxide
(DMSO), 6 nmol rosiglitazone (RGZ) or 500 ng GW9662. (A) Changes in O2
·- production. (B) Changes in protein oxidation. Values are mean ± standard error of the mean (SEM) of quadruplicate analyses from four animals per experimental group. *P < 0.05 versus sham-control group, +P < 0.05 versus sham-control, DMSO + KA or GW9662 + KA group, and #P < 0.05 versus sham-control, DMSO + KA or RGZ + KA group in the Scheffé multiple-range test.