Figure 1

Cerebrospinal fluid (CSF) apoC-I is reduced in human subjects carrying an APOE ϵ4 allele. CSF obtained via lumbar sac puncture from normal volunteers 65 years or older who enrolled in two recent intervention studies was assayed for apoC-I (n = 63). CSF was collected from initial lumbar tap prior to treatment protocol assignment. Results were stratified by APOE with 36 individuals homozygous for APOE ϵ3 and 27 individuals either homozygous for APOE ϵ4 or heterozygous APOE ϵ3 and ϵ4. There were too few (n = 7) individuals in this data set with APOE ϵ2. Individuals with an APOE ϵ4 allele had approximately 15% lower CSF apoC-I than individuals homozygous for APOE ϵ3 (P = 0.02).