The appearance of differentiated SH-SY5Y cells after IL-18 or IL-1β treatments with or without amyloid-β42 addition. (A) Differentiated untreated control cells. (B) The cells were treated with IL-18 (100 ng/mL) or (C) with IL-1β (50 ng/mL) for 72 h. IL-1β exposed cells seemed to be more vacuolized than the control cells or IL-18 treated cells. The cells were treated (D) with 1 μM Aβ42 only, (E) with IL-18 (100 ng/mL), and 1 μM Aβ42 for 72 h, (F) with IL-1β (50 ng/mL) and 1 μM Aβ42 for 72 h. The arrowheads indicate the clustering of the cells. Magnification 200x, bar 10 μm as shown in (A).