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Table 1 Mean percentage alteration of protein levels of IL-18 treated targets compared to untreated ones, analyzed from western blots

From: Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells

   6 h 24 h 48 h 72 h
APP, approximately  100 kD Mean % ± SEM 74.9 ±17.2 19.3 ±9.9 56.5 ±12.4 −3.0 ±10.1
  n 20 31 30 31
  t-Test, P <0.000 a 0.062 <0.000 a 0.769
  M-W, P 0.001 a 0.809 <0.000 a 0.243
BACE-1, approximately 70 kD Mean % ± SEM 35.1 ±29.7 131.1 ±35.4 39.1 ±25.1 67.8 ±21.5
  N 11 20 18 19
  t-Test, P 0.107 0.002 b 0.310 0.006 b
  M-W, P 0.700 <0.000 a 0.543 <0.000 a
PS-1, approximately 34 kD Mean % ± SEM 191.9 ±80.7 22.6 ±28.4 26.5 ±25.9 5.4 ±16.0
  n 7 17 16 18
  t-Test, P 0.055 0.322 0.323 0.741
  M-W, P 0.017 c 0.734 0.519 1.000
PS-1, approximately 53 kD Mean % ± SEM 121.9 ±68.7 67.0 ±32.9 26.0 ±12.3 −18.9 ±10.4
  n 9 18 18 18
  t-Test, P 0.114 0.058 0.050c 0.087
  M-W, P 0.203 0.543 0.068 0.543
PS-1, approximately 100 kD Mean % ± SEM 79.7 ±55.9 51.4 ±19.2 27.8 ±16.4 8.1 ±12.1
  n 10 19 19 20
  t-Test, P 0.106 0.138 0.767 0.247
  M-W, P 0.192 0.016 c 0.106 0.377
bcl-xL, approximately 30 kD Mean % ± SEM 20.7 ±36.6 −6.3 ±11.2 17.7 ±19.5 23.5 ±8.7
  n 5 15 14 14
  t-Test, P 0.602 0.582 0.381 0.018 c
  M-W, P 0.577 0.319 0.034 c 0.039 c
  1. SEM, Standard error of mean; n, number of repeats; t-Test, Student’s t-Test; M-W, Mann–Whitney U-Test; P, P value.
  2. a P value, 0.001.
  3. b P value, 0.01.
  4. c P value, 0.05.
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Journal of Neuroinflammation

ISSN: 1742-2094