Journal of Neuroinflammation

Table 1 Mean percentage alteration of protein levels of IL-18 treated targets compared to untreated ones, analyzed from western blots

From: Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells

		6 h	24 h	48 h	72 h
APP, approximately 100 kD	Mean % ± SEM	74.9 ±17.2	19.3 ±9.9	56.5 ±12.4	−3.0 ±10.1
	n	20	31	30	31
	t-Test, P	*<0.000* ^a	0.062	*<0.000* ^a	0.769
	M-W, P	*0.001* ^a	0.809	*<0.000* ^a	0.243
BACE-1, approximately 70 kD	Mean % ± SEM	35.1 ±29.7	131.1 ±35.4	39.1 ±25.1	67.8 ±21.5
	N	11	20	18	19
	t-Test, P	0.107	*0.002* ^b	0.310	*0.006* ^b
	M-W, P	0.700	*<0.000* ^a	0.543	*<0.000* ^a
PS-1, approximately 34 kD	Mean % ± SEM	191.9 ±80.7	22.6 ±28.4	26.5 ±25.9	5.4 ±16.0
	n	7	17	16	18
	t-Test, P	0.055	0.322	0.323	0.741
	M-W, P	*0.017* ^c	0.734	0.519	1.000
PS-1, approximately 53 kD	Mean % ± SEM	121.9 ±68.7	67.0 ±32.9	26.0 ±12.3	−18.9 ±10.4
	n	9	18	18	18
	t-Test, P	0.114	0.058	*0.050*c	0.087
	M-W, P	0.203	0.543	0.068	0.543
PS-1, approximately 100 kD	Mean % ± SEM	79.7 ±55.9	51.4 ±19.2	27.8 ±16.4	8.1 ±12.1
	n	10	19	19	20
	t-Test, P	0.106	0.138	0.767	0.247
	M-W, P	0.192	*0.016* ^c	0.106	0.377
bcl-xL, approximately 30 kD	Mean % ± SEM	20.7 ±36.6	−6.3 ±11.2	17.7 ±19.5	23.5 ±8.7
	n	5	15	14	14
	t-Test, P	0.602	0.582	0.381	*0.018* ^c
	M-W, P	0.577	0.319	*0.034* ^c	*0.039* ^c

SEM, Standard error of mean; n, number of repeats; t-Test, Student’s t-Test; M-W, Mann–Whitney U-Test; P, P value.
^a P value, 0.001.
^b P value, 0.01.
^c P value, 0.05.

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ISSN: 1742-2094

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