6 h | 24 h | 48 h | 72 h | ||
---|---|---|---|---|---|
APP, approximately 100 kD | Mean % ± SEM | 74.9 ±17.2 | 19.3 ±9.9 | 56.5 ±12.4 | −3.0 ±10.1 |
n | 20 | 31 | 30 | 31 | |
t-Test, P | <0.000 a | 0.062 | <0.000 a | 0.769 | |
M-W, P | 0.001 a | 0.809 | <0.000 a | 0.243 | |
BACE-1, approximately 70 kD | Mean % ± SEM | 35.1 ±29.7 | 131.1 ±35.4 | 39.1 ±25.1 | 67.8 ±21.5 |
N | 11 | 20 | 18 | 19 | |
t-Test, P | 0.107 | 0.002 b | 0.310 | 0.006 b | |
M-W, P | 0.700 | <0.000 a | 0.543 | <0.000 a | |
PS-1, approximately 34 kD | Mean % ± SEM | 191.9 ±80.7 | 22.6 ±28.4 | 26.5 ±25.9 | 5.4 ±16.0 |
n | 7 | 17 | 16 | 18 | |
t-Test, P | 0.055 | 0.322 | 0.323 | 0.741 | |
M-W, P | 0.017 c | 0.734 | 0.519 | 1.000 | |
PS-1, approximately 53 kD | Mean % ± SEM | 121.9 ±68.7 | 67.0 ±32.9 | 26.0 ±12.3 | −18.9 ±10.4 |
n | 9 | 18 | 18 | 18 | |
t-Test, P | 0.114 | 0.058 | 0.050c | 0.087 | |
M-W, P | 0.203 | 0.543 | 0.068 | 0.543 | |
PS-1, approximately 100 kD | Mean % ± SEM | 79.7 ±55.9 | 51.4 ±19.2 | 27.8 ±16.4 | 8.1 ±12.1 |
n | 10 | 19 | 19 | 20 | |
t-Test, P | 0.106 | 0.138 | 0.767 | 0.247 | |
M-W, P | 0.192 | 0.016 c | 0.106 | 0.377 | |
bcl-xL, approximately 30 kD | Mean % ± SEM | 20.7 ±36.6 | −6.3 ±11.2 | 17.7 ±19.5 | 23.5 ±8.7 |
n | 5 | 15 | 14 | 14 | |
t-Test, P | 0.602 | 0.582 | 0.381 | 0.018 c | |
M-W, P | 0.577 | 0.319 | 0.034 c | 0.039 c |