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Table 2 Protein levels inflammatory mediators

From: Protein expression profiling of inflammatory mediators in human temporal lobe epilepsy reveals co-activation of multiple chemokines and cytokines

Protein

Hippocampal expression (pg/ml)

Cortical expression (pg/ml)

P-value

Chemokines

Cntrl

mTLE-HS

mTLE + HS

Cntrl

mTLE-HS

mTLE + HS

 

CCL22/MDC

0.3

(0–0.7)

0.8

(0.4-1.6)

0.9

(0.3-1.4)

0.2

(0–0.6)

0.6

(0.3-1.2)

0.9

(0.7-1.3)

1.74E-08

CCL5/RANTES

8.1

(4–15.8)

77.4

(40.9-238.1)

49.4

(18.5-167.7)

10.9

(1.6-18.5)

26.0

(18.5-122.3)

31.5

(17.4-38.5)

1.60E-08

CCL4/MIP1β

0

(0–0)

19.4

(4–122.3)

18.9

(6.2-95.3)

0

(0–0)

0

(0–7.6)

0.0

(0–33.6)

2.11E-08

CXCL9/MIG

3.2

(1.1-11)

9.0

(6.7-16.7)

11.0

(4.4-17.1)

5.7

(2.4-7.7)

8.3

(5.7-12)

10.7

(7.0-12.3)

5.99E-07

CCL2/MCP1

1.1

(0–4.3)

11.4

(2.1-52.8)

9.3

(2.1-29.0)

0.0

(0–2.9)

0.7

(0–4.6)

0.3

(0–18.2)

4.13E-06

CCL3/MIP1α

44.4

(11.2-106.2)

94.5

(62–177.4)

94.6

(62–317.1)

35.6

(20.1-57.4)

62.0

(35.6-104.9)

85.1

(59.0-97.2)

9.13E-05

CCL19/MIP3β

0

(0–0)

0.5

(0–1.6)

0

(0–1)

0

(0–0)

0

(0–1.7)

0.4

(0–1.3)

9.90E-05

CCL18/PARC

16.6

(0.2-151.6)

24.2

(1.8-177.4)

14.0

(0–29.5)

13.7

(0–132.7)

3.3

(0–31.9)

0.7

(0–37.6)

0.001966

CXCL8/IL-8

0.8

(0–13.8)

2.7

(0–26)

1.0

(0.3-20.1)

0.6

(0–1.6)

0.5

(0–10.3)

0.9

(0–3.6)

0.02352

CCL11/Eotaxin

0

 

0

 

0

 

0

 

0

 

0

 

b.d.

CCL17/Tarc

0

 

0

 

0

 

0

 

0

 

0

 

b.d.

CXCL10/IP-10

0

 

0

 

0

 

0

 

0

 

0

 

b.d.

Cytokines

             

IL-7

0

(0–5.6)

8.3

(3.8-9.6)

7.3

(0.6-12.2)

0.9

(0.0-4.6)

8.7

(4.6-14.5)

11.0

(8–12.7)

5.07E-15

IL-13

2.6

(0.9-6.8)

13.4

7.9-20.5)

11.2

(8.1-17.4)

6.4

(2.6-12.5)

12.7

(10.3-17.4)

15.4

(10.7-16.5)

7.60E-13

IL-22

92.5

(58.3-212.2)

351.2

(236.6-540.6)

304.1

(244.8-449.9)

212.2

(122.8-359.4)

380.0

(293.8-548.8)

425.2

(261.1-499.3)

1.65E-12

IL-5

0

(0–1.2)

2.8

(1.5-7.4)

2.8

(0.3-5.5)

0

(0–1)

2.3

(1–6.7)

5.0

(2–6.1)

2.06E-07

IL-25/IL-17E

726.9

(273.4-1780)

868.3

(348.3-1616)

1976.4

(258.5-2499)

303.3

(109.9-757.4)

673.5

(483.8-1234.5)

922.1

(468.7-1327.5)

1.93E-05

IL-1RA

13.5

(6.7-26.8)

19.0

(13.5-33.4)

20.7

(12.3-29)

15.7

(13.5-31.2)

29.0

(13.5-165.2)

53.1

(26.8-92.2)

2.96E-05

IL-1a

0

(0–0.2)

0.3

(0–3)

0.3

(0–1.3)

0

(0–0)

0

(0–0.9)

0.3

(0–1.6)

5.06E-05

IL-27

40.9

(0–153.8)

33.7

(0–133.4)

132.1

(0–370.5)

0

(0–42.3)

28.6

(0–89.7)

49.4

(29.4-78.7)

8.93E-05

IL-10

2.2

(0–5.9)

1.4

(0–3.4)

7.8

0-12.4)

0

(0–2.2)

0.5

(0–1.9)

0.9

(0–3.4)

1.02E-04

IFNα

22.5

(12.8-41.5)

31.5

(22.7-58.5)

66.3

(10.1-114.3)

27.0

(4.1-73.1)

41.3

(26.9-51.5)

38.5

(30.7-59)

3.40E-04

MIF

11135.4

(7054–13156)

8200.7

(6406–19843)

6907.3

(4910–9650)

11062.2

(4645–17980)

7112.0

(4645–9872)

7180.8

(5547–9470)

0.0024

IL-1β

0.2

(0–0.9)

0.8

(0.2-1.7)

0.9

(0–1.7)

0.2

(0–0.9)

0.5

(0–1.5)

0.9

(0–1.7)

0.0063

IL-23

298.9

(190.4-568.7)

575.1

(473.2-675)

556.2

(311.2-691)

308.1

(238.2-717)

500.2

(286.7-633)

543.2

(372.9-710)

0.0063

IL-4

0

(0–0.1)

0.1

(0–0.2)

0

(0–0.2)

0

(0–0)

0

(0–0.2)

0.1

(0–0.2)

0.0234

IL-6

0

(0–11.7)

0

(0–3.9)

0

(0–1.1)

0

(0–2.1)

0

(0–0)

0.0

(0–0)

0.0428

IL-21

336.5

(117.7-944.2)

510.6

(0–944.2)

831.0

(55.8-1270.4)

431.2

(0–1009.1)

415.4

(0–847.1)

654.1

(179.9-1534)

0.0848

TNFα

10.4

(8.6-12.7)

11.5

(7.0-13.2)

11.2

(8.2-13.2)

9.3

(6.3-12.9)

10.6

(6.9-12.3)

10.5

(9.2-13.2)

0.1341

IL-18

3.7

(1.7-14.2)

3.2

(1.5-5.2)

2.1

(1.1-23.8)

5.0

(1.6-163.1)

2.9

(1.7-12.4)

2.9

(2.2-4.8)

0.1481

IL-6R

1.4

(0–10)

1.4

(0–5.6)

4.5

(1.4-8.9)

3.4

(0–17)

3.4

(0–10)

4.5

(0–7.8)

0.4944

IL-2

0

 

0

 

0

 

0

 

0

 

0.0

 

b.d.

IL-12p70

0

 

0

 

0

 

0

 

0

 

0.0

 

b.d.

Other

             

VCAM1

219.7

(33.9-828.3)

985.5

(548–1722.6)

1181.3

(364.5-1649)

210.3

67.3-527.2)

817.5

(444.9-1287)

1239.9

(740.4-1551)

2.71E-11

VEGF

10.0

(0.4-28.8)

30.3

(18.6-47)

31.1

(7.2-59.3)

4.5

(0–12.8)

22.9

(12.8-39.3)

32.6

(17.1-36.3)

3.70E-10

HGF

33.0

(26.7-54.5)

105.2

(65.8-157.4)

90.3

(34.6-156.4)

24.0

(19–50.3)

71.3

(37–207.7)

52.4

(32.2-83.6)

1.38E-07

ICAM1

9099.6

(3364–17901)

5400.2

(3174–9985)

16011.1

(5781–26620)

5039.5

(1532–16739)

3440.4

(1532–10754)

4698.9

(1861–8725)

9.13E-05

Cathepsin S

463.3

(284.2-1010)

311.9

(129.1-525.7)

218.0

(160.4-425.5)

350.6

(198.2-993.6)

303.8

(198.2-478.7)

327.2

(190.4-413)

0.0025

TIMP-1

101.0

(36.2-2243.7)

124.3

(81.6-382.5)

103.2

(50.7-204)

81.6

(53.7-137.7)

97.7

(64.5-324.4)

112.5

(83.5-305.6)

0.2672

Adiponectin

415.0

(14–1412.5)

727.8

(193.3-1643)

480.3

(221–1787.4)

722.4

(22.4-1979.9)

490.0

(22.4-940.7)

349.3

(0–1751)

0.4253

  1. MIA was performed on selected chemokines, cytokines, growth factors and adhesion molecules. HC and CX protein levels were determined in controls and 2 mTLE patient groups (− and + HS).Inflammatory proteins are listed in order of overall significance (ANOVA/Kruskal-Wallis). Proteins in bold show significant changes between groups (ANOVA/Kruskal-Wallis, p < 0.0015). Levels are presented as medians and range (between brackets). Abbreviations: b.d. below detection, HGF hepatocyte growth factor, ICAM1 intercellular cell adhesion molecule 1, IFNα interferon type 1α, IP10 Interferon gamma-induced protein 10, MCP1 macrophage derived chemokine, MDC macrophage derived chemokine, MIF Macrophage migration inhibitory factor, MIG monokine induced by interferon γ, MIP1α Macrophage inflammatory protein-1α, MIP1β Macrophage inflammatory protein-1β, MIP3β Macrophage inflammatory protein-3β, PARC pulmonary and activation-regulated chemokine, RANTES Regulated upon activation normal T cell express sequence, TARC thymus and activation regulated chemokine, TIMP-1 tissue inhibitor of metalloproteinases, TNFα tumor necrosis factor, VCAM1 vascular cell adhesion molecule 1, VEGF vascular endothelial growth factor.
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Journal of Neuroinflammation

ISSN: 1742-2094