Journal of Neuroinflammation

Table 5 Association between IL-6 haplotypes and LOAD

From: Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease

	Prevalence in controls, %	2 copies		1 or 0 copies
		Case/Control	AOR	Case/Control	AOR (95% CI)	p
HAP1 (CAT)^a	73.3	159/244	1.00	107/200	0.65 (0.44-0.95)	0.02
ApoE e4 non-carriers		99/206	1.00	62/170	0.57 (0.36-0.91)	0.02
ApoE e4 carriers		59/37	1.00	45/29	0.85 (0.42-1.76)	0.67
	Prevalence in controls, %	0 copies		1 or 2 copies
		Case/Control	AOR	Case/Control	AOR (95% CI)	p
HAP2 (GGC)	17.8	263/439	1.00	3/5	1.10 (0.16-7.58)	0.92
HAP3 (GAC)	8.1	260/442	1.00	6/2	2.56 (0.39-16.95)	0.33

^a Two copies of HAP1 was used as the reference group because it is a "major" haplotype (haplotype frequency > 0.5).
Abbreviations: AOR, adjusted odds ratio; HAP, haplotype; LOAD, late-onset Alzheimer's disease.
All models were adjusted for age, gender, education, and ApoE e4 status.

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ISSN: 1742-2094

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