Oxidative stress in RVLM underpins hypertension induced by intraperitoneal infusion of LPS. Changes in MSAP (A,B) or plasma level of CRP (C) determined on day 7 after intraperitoneal infusion of saline or LPS (1.2 mg/kg/day), alone or with additional intracisternal infusion of aCSF or tempol (1μmol/μL/h) (A,C), or microinjection bilaterally into RVLM of tempol (100 pmol) (B). Values are mean ± SEM (n=8 to 10 animals in each experimental group). *P <0.05 vs. saline-treatment or sham-control group; #
P <0.05 vs. LPS-treatment group in the post hoc Scheffé multiple-range test.