Physiological parameters in control and STZ-treated rats. Values of (A) blood glucose (mmol/l); (B) body weight (g); (C) water intake (ml/day); and (D) food consumption (g/day) before (Day 0) and after (Day 7) STZ treatment (65 mg/kg, i.p.) or its vehicle (Control). Statistical comparison is indicated between Day 0 and Day 7 (***P <0.001) and between control and STZ-treated rats on Day 7 (+++P <0.001). n = 5 to 7 rats.