Cellular sources of dysregulated cytokines in relapsing-remitting multiple sclerosis

Romme Christensen, Jeppe; Börnsen, Lars; Hesse, Dan; Krakauer, Martin; Sørensen, Per Soelberg; Søndergaard, Helle Bach; Sellebjerg, Finn

doi:10.1186/1742-2094-9-215

Journal of Neuroinflammation

Table 5 Correlations between cytokine and cell type marker expression in cerebrospinal fluid cells

From: Cellular sources of dysregulated cytokines in relapsing-remitting multiple sclerosis

			RRMS relapse and NIND				RRMS relapse
CSF NR			N	R	p-value	q-value	N	R	p-value	q-value
*IFNG*	vs	*CD3d*	22	0.383	0.08	0.06	12	0.441	0.151	0.39
*IFNG*	vs	*CD14*	22	−0.606	0.003	0.008	12	0.018	0.956	0.90
*IFNG*	vs	*CD19*	22	0.538	0.010	0.02	12	0.111	0.731	1.04
*IFNG*	vs	*CD56*	22	0.372	0.09	0.06	12	0.019	0.954	0.93
*IL1B*	vs	*CD3d*	23	−0.453	0.03	0.03	13	0.064	0.837	0.89
*IL1B*	vs	*CD14*	23	0.126	0.57	0.27	13	0.067	0.829	0.91
*IL1B*	vs	*CD19*	23	0.168	0.44	0.21	13	0.435	0.137	0.39
*IL1B*	vs	*CD56*	23	0.110	0.62	0.28	13	0.285	0.345	0.73
*IL7*	vs	*CD3d*	23	0.090	0.68	0.30	13	−0.121	0.694	1.03
*IL7*	vs	*CD14*	23	−0.169	0.44	0.22	13	0.087	0.777	0.98
*IL7*	vs	*CD19*	23	0.600	0.002	0.009	13	0.513	0.073	0.36
*IL7*	vs	*CD56*	23	0.412	0.05	0.04	13	0.241	0.429	0.86
*IL10*	vs	*CD3d*	23	−0.506	0.01	0.02	13	−0.589	0.034	0.23
*IL10*	vs	*CD14*	23	0.773	0.00002	0.00011	13	0.541	0.056	0.32
*IL10*	vs	*CD19*	23	−0.438	0.04	0.04	13	−0.151	0.623	1.01
*IL10*	vs	*CD56*	23	−0.242	0.27	0.15	13	0.086	0.781	0.95
*IL12A*	vs	*CD3d*	23	0.075	0.73	0.31	13	−0.096	0.755	1.03
*IL12A*	vs	*CD14*	23	−0.327	0.13	0.08	13	−0.236	0.437	0.78
*IL12A*	vs	*CD19*	23	0.577	0.004	0.008	13	0.508	0.076	0.32
*IL12A*	vs	*CD56*	23	0.756	0.00003	0.00014	13	0.697	0.008	0.09
*IL15*	vs	*CD3d*	23	0.226	0.30	0.16	13	0.067	0.828	0.94
*IL15*	vs	*CD14*	23	−0.519	0.01	0.02	13	−0.450	0.123	0.42
*IL15*	vs	*CD19*	23	0.847	0.0000003	0.0000048	13	0.758	0.003	0.09
*IL15*	vs	*CD56*	23	0.469	0.02	0.03	13	0.349	0.242	0.59
*IL23*	vs	*CD3d*	23	0.004	0.98	0.39	13	0.034	0.912	0.91
*IL23*	vs	*CD14*	23	−0.396	0.06	0.05	13	−0.040	0.898	0.92
*IL23*	vs	*CD19*	23	0.340	0.11	0.07	13	0.177	0.562	0.96
*IL23*	vs	*CD56*	23	0.234	0.28	0.15	13	0.092	0.766	1.00
*LTA*	vs	*CD3d*	23	0.002	0.99	0.39	13	−0.121	0.693	1.07
*LTA*	vs	*CD14*	23	−0.420	0.05	0.04	13	−0.078	0.800	0.94
*LTA*	vs	*CD19*	23	0.563	0.005	0.009	13	0.461	0.113	0.43
*LTA*	vs	*CD56*	23	0.384	0.07	0.05	13	0.238	0.433	0.82
*LTB*	vs	*CD3d*	23	0.579	0.004	0.009	13	0.440	0.133	0.41
*LTB*	vs	*CD14*	23	−0.057	0.80	0.33	13	0.305	0.310	0.70
*LTB*	vs	*CD19*	23	−0.337	0.12	0.07	13	−0.702	0.008	0.13
*LTB*	vs	*CD56*	23	−0.304	0.16	0.09	13	−0.598	0.031	0.26

Gene expression data are shown as the normalization ratio (NR). Correlation analysis was done with Spearman’s rank correlation coefficient, and q-values represent the false discovery rate corrected P-values. Significant values are in bold. RRMS relapse: Relapsing-remitting multiple sclerosis patients in relapse. CSF cerebrospinal fluid; NIND, Non-inflammatory neurological disease; PBMC, Peripheral blood mononuclear cell.

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ISSN: 1742-2094

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