Figure 4
From: Complement is dispensable for neurodegeneration in Niemann-Pick disease type C
C1q localizes to the perineuronal ECM in the CA2 hippocampus and cerebellar DCN. (A) In Npc1 -/- mice, C1q (red) partially localizes with CSPG (green) of CA2 neurons. Matched image from a C1qa -/-; Npc1 -/- mouse is shown as a control for the C1q antibody used. Sr denotes the stratum radiatum side of the CA2 field. CA2 neuron bodies (blue) are marked with Nissl stain. Scale bars are 50μm. (B) A single cerebellar DCN neuron is shown. Scale bar is 10μm.