Toll-like receptors 4 and 9 are responsible for the maintenance of the inflammatory reaction in canine steroid-responsive meningitis-arteritis, a large animal model for neutrophilic meningitis

Maiolini, Arianna; Carlson, Regina; Tipold, Andrea

doi:10.1186/1742-2094-9-226

Journal of Neuroinflammation

Table 3 Expression of TLRs in/on leukocytes in SRMA (percentage of positive cells, median and 25% to 75% range)

From: Toll-like receptors 4 and 9 are responsible for the maintenance of the inflammatory reaction in canine steroid-responsive meningitis-arteritis, a large animal model for neutrophilic meningitis

TLRs	SRMA A	significant differences (P <0.05)	tendencies
CSF PMNs	SRMA A	significant differences (P <0.05)	tendencies
TLR3	2.4 (1.5 to 3.7)	none	Neopl↑
TLR9	94.1 (53.8 to 99.0)	none
TLR2	83.8 (79.6 to 90.9)	none
TLR4	93.1 (81.7 to 95.3)	MUE↓
TLR4	93.1 (81.7 to 95.3)	Neopl↓
TLR5	91.6 (70.9 to 95.3)	MUE↓
TLR5	91.6 (70.9 to 95.3)	Neopl↓
CSF monocytes
TLR3	14.4 (3.7 to 30.5)	none
TLR9	85.0 (48.0 to 95.0)	none	MUE↓
TLR2	87.0 (78.9 to 94.3)	none	MUE↓
TLR4	82.6 (74.5 to 93.2)	none
TLR5	83.3 (62.8 to 94.1)	none
CSF lymphocytes
TLR3	2.9 (1.0 to 11.6)	none	SRMA Th↑
TLR9	2.9 (18.8 to 1.5)	none	mix↓
TLR2	13.0 (8.1 to 18.0)	BM↓
TLR2	13.0 (8.1 to 18.0)	MUE↓
TLR4	13.0 (3.0 to 23.9)	SRMA Th↑
		BM↓
		Mix↑
TLR5	11.1 (3.7 to 18.8)	none	BM↓
PB PMNs
TLR3	7.5 (5.3 to 11)	Pyo↓	Neopl↑
TLR3	7.5 (5.3 to 11)	Pyo↓	Healthy↑
TLR9	96.3 (60.8 to 97.7)	Healthy↓	Mix↓
TLR2	98.7 (98.1 to 99.3)	Healthy↓	SRMA Th↓
TLR2	98.7 (98.1 to 99.3)	Healthy↓	Mix↓
TLR4	98.6 (98.1 to 99.7)	Healthy↓
TLR4	98.6 (98.1 to 99.7)	Mix↓
TLR5	99.0 (97.4 to 99.5)	Healthy↓
PB monocytes
TLR3	8.6 (4.5. to 15.21)	Pyo↓	Neopl↑
TLR3	8.6 (4.5. to 15.21)	Pyo↓	Healthy↓
TLR9	92.1 (67.2 to 96.9)	SRMA Th↓	Pyo↓
TLR9	92.1 (67.2 to 96.9)	Healthy↓	Pyo↓
TLR2	96.3 (94.0 to 97.9)	SRMA Th↓
		Neopl↓
		Mix↓
TLR4	95.6 (93.3 to 96.9)	SRMA Th↓	Neopl↓
		Mix↓
		Healthy↓
TLR5	95.3 (92.3 to 97.4)	Healthy↓	Mix↓
PB lymphocytes
TLR3	4.0 (3.1 to 5.8)	none
TLR9	85.2 (71.2 to 92.8)	none	Pyo↓
TLR9	85.2 (71.2 to 92.8)	none	Healthy↓
TLR2	6.4 (4.5 to 13.6)	BM↓	MUE↑
TLR2	6.4 (4.5 to 13.6)	Healthy↑	Neopl↑
TLR4	8.2 (3.8 to 13.5)	BM↓	Pyo↑
TLR4	8.2 (3.8 to 13.5)	Healthy↑	Pyo↑
TLR5	6.125 (4.4 to 18.7)	none	BM↓
TLR5	6.125 (4.4 to 18.7)	none	Healthy↑

BM, bacterial meningitis; Healthy, healthy dogs; Mix, miscellaneous diseases of the nervous system; MUE, meningoencephalitis of unknown etiology; PMNs, polymorphonuclear cells; Pyo, pyogenic infection; SRMA, steroid-responsive meningitis-arteritis; SRMA A, SRMA acute; SRMA Th, SRMA under therapy; TLR, Toll-like receptor.
(↓) lower or (↑) higher values in comparison to SRMA A.

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ISSN: 1742-2094

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