Figure 1

Cytokine and chemokine gene expression. TNF-α mRNA levels in the hippocampus were significantly elevated in LPS-vehicle rats (*p < 0.05 vs. aCSF-vehicle rats) and reduced to control levels in LPS-DT rats (#p < 0.05 vs. aCSF-vehicle rats). TNFR2 mRNA levels were significantly elevated in LPS-vehicle rats (*p < 0.05 vs. aCSF-vehicle) and similarly lowered to control levels in LPS-DT rats (##p < 0.01 vs. LPS-vehicle; not significant vs. aCSF-vehicle). IL-1β mRNA levels were significantly increased compared to aCSF-V levels in both LPS-vehicle and LPS-DT groups (***p < 0.001 and *p < 0.05 vs. aCSF-vehicle rats). However, DT treatment did induce a significant reduction in the gene transcript level compared to the LPS-vehicle group (#p < 0.05 vs. LPS-vehicle rats). Treatment with LPS and/or DT induced no significant differences in gene transcript levels for IL-6, IL-4 and CX3CL1 and CD200.