Table 1 Summary and overview of the main characteristics of SJL PLP139-151 peptide immunized mice and C57 MOG35-55 peptide immunized mice
From: Pain in experimental autoimmune encephalitis: a comparative study between different mouse models
Parameter | SJL-PLP139-151 | C57-MOG35-55 |
|---|---|---|
Thermal hyperalgesia | ||
Onset | + | ∅ |
Peak | + | ∅ |
Chronic | ++ | + |
Mechanical allodynia | ||
Onset | ∅ | (+) |
Peak | ∅ | (+) |
Chronic | ++ | ∅ |
Microglia activation | ||
Onset | + | + |
Peak | +++ | ++ |
Chronic | ++ | + |
Astrocyte activation | ||
Onset | + | ++ |
Peak | ++ | ++ |
Chronic | +++ | ++ |