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Table 1 Summary and overview of the main characteristics of SJL PLP139-151 peptide immunized mice and C57 MOG35-55 peptide immunized mice

From: Pain in experimental autoimmune encephalitis: a comparative study between different mouse models

Parameter SJL-PLP139-151 C57-MOG35-55
Thermal hyperalgesia   
Onset +
Peak +
Chronic ++ +
Mechanical allodynia   
Onset (+)
Peak (+)
Chronic ++
Microglia activation   
Onset + +
Peak +++ ++
Chronic ++ +
Astrocyte activation   
Onset + ++
Peak ++ ++
Chronic +++ ++
  1. Behavioral and immunohistochemical characteristics indicate that SJL-EAE mice develop much more pain and show stronger microglia and astrocyte activation.