Figure 1

Experimental design. Mice received four injections of the neurotoxin MPTP (15 mg/kg; MPTP group) or an equivalent volume of saline (vehicle group) every 2 hours on day 0. Twenty hours after the last injection, mice received intraperitoneal injections of 30 mg intravenous immunoglobulin (IVIg) or an equivalent volume of 0.2 M glycine pH 4.0 (control group) on the first day (bolus) and 10 mg daily (maintenance dose) for the remaining 13 days. Mice were sacrificed on day 15 by intracardiac perfusion under deep anesthesia.