Figure 6

Interleukin and neurotrophin mRNA levels after axotomy. (A,B) Graphs showing interleukin (IL)-6 and IL-1β mRNA expression in the lumbar spinal cord of C57BL/6J wild-type (WT) and Toll-like receptor (TLR)2 knockout (KO) mice (TLR2^−/−). (C,D) Graphs showing IL-6 and IL-1β mRNA expression in the lumbar spinal cord of C3H/HePas WT and C3H/HeJ TLR4 mutants. (E,F) Graphs showing brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) mRNA levels in the lumbar spinal cord of C57BL/6J WT and TLR2^−/− mice. (G,H) Graphs showing BDNF and GDNF mRNA levels in the lumbar spinal cord of C3H/HePas WT and C3H/HeJ TLR4 mutants. Note that the absence of TLR2 downregulated IL-6 and IL-1β, and upregulated GDNF and BDNF mRNA expression after unilateral sciatic nerve axotomy, whereas the mutation of TLR4 resulted in upregulation of IL-6 and downregulation of GDNF mRNA. * P<0.05Scale Bar: 50 μm.