Rescue from acute neuroinflammation by pharmacological chemokine-mediated deviation of leukocytes

Table 1 Hyperacute EAE development in SJL/J mice treated with COAM

	Day 0		Day 8		Day 0 + 7
	saline	COAM	saline	COAM	saline	COAM
Mean maximum disease score ± SEM	5.6 ± 0.25	3.8 ± 0.78*	3.6 ± 0.75	4.6 ± 0.62	5.75 ± 0.24	2.72 ± 0.79*
Incidence	10/10	5/10*	8/10	9/10	10/10	6/9
Mortality	8/10	5/10	4/10	6/10	9/10	2/9**
Mean day of onset ± SEM	12.3 ± 0.2	13.1 ± 0.37	13 ± 0.56	12.2 ± 0.14	11.8 ± 0.28	12.8 ± 0.37

SJL/J mice were immunized subcutaneously with syngeneic SCH for induction of EAE as described in Materials and Methods. They were treated i.p. with 2 mg COAM or saline on the indicated days after immunization. Dead animals were scored 6 from the day of death until the end of the study. * P <0.05; ** P <0.01 for comparison with saline-treated group; Wilcoxon test (disease score) or Chi-square test (incidence and mortality). COAM, chlorite-oxidized oxyamylose; EAE, experimental autoimmune encephalomyelitis; SCH, spinal cord homogenate; SEM, standard error of the mean.

ISSN: 1742-2094