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Table 1 Hyperacute EAE development in SJL/J mice treated with COAM

From: Rescue from acute neuroinflammation by pharmacological chemokine-mediated deviation of leukocytes

  Day 0 Day 8 Day 0 + 7
  saline COAM saline COAM saline COAM
Mean maximum disease score ± SEM 5.6 ± 0.25 3.8 ± 0.78* 3.6 ± 0.75 4.6 ± 0.62 5.75 ± 0.24 2.72 ± 0.79*
Incidence 10/10 5/10* 8/10 9/10 10/10 6/9
Mortality 8/10 5/10 4/10 6/10 9/10 2/9**
Mean day of onset ± SEM 12.3 ± 0.2 13.1 ± 0.37 13 ± 0.56 12.2 ± 0.14 11.8 ± 0.28 12.8 ± 0.37
  1. SJL/J mice were immunized subcutaneously with syngeneic SCH for induction of EAE as described in Materials and Methods. They were treated i.p. with 2 mg COAM or saline on the indicated days after immunization. Dead animals were scored 6 from the day of death until the end of the study. * P <0.05; ** P <0.01 for comparison with saline-treated group; Wilcoxon test (disease score) or Chi-square test (incidence and mortality). COAM, chlorite-oxidized oxyamylose; EAE, experimental autoimmune encephalomyelitis; SCH, spinal cord homogenate; SEM, standard error of the mean.