Figure 2

No difference in mononucleated cell infiltration between EAE-induced Prnp ^-/- and Prnp ^+/+ mice. Hematoxylin stained sections of ventral spinal cord at 22 dpi; (A) Prnp ^+/+ EAE-induced mouse; (B) Prnp ^-/- EAE-induced mouse and (C) non-EAE PBS/CFA control. (D) and (E) white matter sections of a Prnp ^-/- PBS control and a Prnp ^-/- EAE mouse respectively. Scale bar: A-C, 200 μm; D-E, 56 μm. (F) average numbers of white matter nuclei per spinal cord section of Prnp ^+/+ and Prnp ^-/- EAE mice and of PBS controls (n = 3/group). *: p < 0.001 versus controls (Dunn's post test analysis).