Figure 5

Less severe EAE in CD3ε ^-/- mice adoptively transferred with PrPc-deficient 2D2 T cells. (A) clinical scores (mean ± SEM). All the mice transferred with PrPc-expressing effector T cells reached terminal stage disease (mean score 4.5) at 20 dpi whereas the average score in the recipients of PrPc-deficient T cells was 1.7 at the same time point. (B) Corresponding weight loss in recipients of PrPc-expressing or deficient 2D2 T cells (mean ± SEM).