Figure 6

More severe EAE in chimeric mice with PrPc-depleted CNS cells. (A) clinical scores in reciprocal BM chimeras (continuous lines, mean ± SEM) and irradiation controls restored with homologous BM (dashed lines, mean). Clinical scores begin diverging at 11 dpi. *: p < 0.05; **: p < 0.01 by Mann-Whitney. (B) Corresponding weight loss (mean ± SEM) associated to EAE exacerbation in [Prnp ^+/+ >Prnp ^-/-] chimeras. Mann-Whitney statistical difference between [Prnp ^+/+ >Prnp ^-/-] vs. [Prnp ^-/- >Prnp ^+/+] chimeras *: p < 0.05; **: p < 0.01.