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Figure 9 | Journal of Neuroinflammation

Figure 9

From: Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells

Figure 9

Potentiation of the IL - 6 - dependent increase of 11β - HSD1 mRNA expression by low concentrations of 11- dehydrocorticosterone . BV-cells were pretreated with 1 μM 11β-HSD1 inhibitor T0504 where indicated for 1 h, followed by addition of 50 nM 11-dehydrocorticosterone with or without 20 ng/mL IL-6 and incubation for another 24 h. 11β-HSD1 mRNA was determined by real-time RT-PCR. Data (mean ± SD from three independent experiments) represent ratios of 11β-HSD1 mRNA to GAPDH control mRNA from treated cells normalized to the values obtained from cells incubated with vehicle (DMSO). **P <0.01, ***P <0.005.

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Journal of Neuroinflammation

ISSN: 1742-2094