Sevoflurane reduces leukocyte infiltration in experimental autoimmune encephalomyelitis (EAE). Representative sagittal sections from (A) oxygen-treated and (B) sevoflurane-treated mice were stained with hematoxylin and eosin to detect infiltrating cells. Arrows indicate large (>5,000 μm2) sites of infiltration; asterisks indicate smaller (<5,000 μm2) sites. The lower images show magnified areas as indicated. (C) The total number of sites of infiltration was quantified as large or small. Data are mean ± SEM of n = 5 sections per animal, three mice in each of the two treatment groups; *P <0.05 versus oxygen.