Figure 7
From: The antiprotozoal drug pentamidine ameliorates experimentally induced acute colitis in mice
(A) Western blot analysis showing S100B protein expression in mucosa (M) and in LMMP preparations. Effect of pentamidine on inflammatory mediators (NO2 -, PGE2, IL-1β, TNF-α) in mucosa (B) and in LMMP (C) in the presence of different proinflammatory stimuli (LPS + DSS or exogenous S100B depending upon the experiments). Results are expressed as mean ± SEM of n = 5 experiments. ***P <0.001 vs. vehicle (saline); °P <0.05, °°P <0.01 and °°°P <0.001 vs. proinflammatory stimulus DSS, dextran sodium sulphate; IL-1β, interleukin-1 beta; LMMP, longitudinal-muscle myenteric plexus; LPS, lipopolysaccharide; NO, nitric oxide; TNF-α, tumor necrosis factor alpha.