Figure 6

Effects of intrathecal ATL on the expression of IL-1β, IL-6 and TNF-α mRNA assessed by RT-PCR in the spinal cords of rats with CIBP. The L4-L5 spinal cords were used to test 2 hours after i.t. injection with ATL (0.3 nmol/20 μl) or NS (20 μl) on day 11 after surgery. Data are expressed as means ± SEM. **P<0.01 versus naive, #P<0.05 versus cancer + NS (by LSD test), ATL, aspirin-triggered-15-epi-lipoxin A4; CIBP, cancer-induced bone pain; i.t., intrathecal; LSD, least-significant difference; NS, normal saline.