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Table 2 Cytokine/Chemokine Profiles in the F344 and HIV-1Tg Rat Brain

From: Endotoxin-induced cytokine and chemokine expression in the HIV-1 transgenic rat

Cytokines and Chemokines in the Brain with LPS Treatment

 

Protein (pg/ml, ± SD)

F344

IL-1β

KC/GRO

IL-4

IL-5

TNF-α

IFN-γ

IL-13

 

Interleukin 1 beta

 

Interleukin 4

Interleukin 5

Tumor necrosis factor - alpha

Interferon gamma

Interleukin 13

SS+S

42.2(± 8.8)

74.4(± 23.3)

ND

56.5(±)

ND

15.3(± 7.5)

4.4(± 1.8)

SS+L

178.4(± 162.1)

1325.3(± 1431.3)

13.5()

102.8(± 61.1)

30.9

20.5(± 11.9)

4.8(± 3.1)

LL+S

59.1(± 26.3)

112.6(± 35.6)

3.4

74.7

ND

14.7(± 7.0)

6.9(± 1.4)

LL+L

207.0(± 133.0)

1036.2(± 685.6)

2.9(± 1.3)

141.9(± 98.3)

ND

21.9(± 6.5)

5.3(± 2.3)

HIV - 1Tg

IL-1β

KC/GRO

IL-4

IL-5

TNF-α

IFN-γ

IL-13

 

Interleukin 1 beta

 

Interleukin 4

Interleukin 5

Tumor necrosis factor - alpha

Interferon gamma

Interleukin 13

SS+S

37.3(± 17.1)

125.3(± 87.8)

ND

ND

ND

11.7(± 5.2)

5.1(± 0.4)

SS+L

361.7(± 104.6)*

2991.3(± 491.5)**

9.2(± 3.1)

164.2(± 35.3)

109.5

47.1(± 14.5)*

9.3(± 4.2)

LL+S

56.5(± 15.1)

128.1(± 61.6)

ND

ND

ND

8.9(± 5.9)

4.6(± 1.4)

LL+L

208.6(± 167.4)

1312.9(± 1039.2)^

8.1(± 1.6)

181.2(± 50.0)

27.3

24.3(± 14.5)^

7.3(± 3.7)

  1. * P < 0.05, ** P < 0.01, *** P < 0.001 greater SS+S control; ^ P < 0.05, ^^ P < 0.01, ^^^ P < 0.001 less than SS+L; statistically significant changes are bolded