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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease

Figure 1

Changes in TH-ir in the substantia nigra and striatum in WT mice. TH-ir at central levels of the substantia nigra (A, C, E, G) and striatum (B, D ,F, H) in WT mice injected with vehicle (controls; A, B), with MPTP alone (C, D), or with MPTP + telmisartan (E, F), or with MPTP + telmisartan + the PPAR-γ antagonist GW9662 (G, H). More TH-ir neurons were observed in the nigra and terminals in the striatum (that is, spared DA neurons and terminals) of mice treated with telmisartan (E, F) than in mice that did not receive telmisartan (C, D) or mice treated with telmisartan and GW9662 (G, H). Scale bar: 250 μm (A, C, E, G) and 560 μm (B, D, F, H).

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