Figure 5

CHPG treatment attenuates NADPH oxidase expression in reactive microglia at four months post-injury. The NADPH oxidase subunit, gp91^phox (red), co-localized (merged) with EDI-positive reactive microglial (magenta) that displayed a hypertrophic or bushy cell morphology (Iba-1; green) in the injured cortex of vehicle-treated TBI samples four months post-TBI. CHPG-treated TBI samples has reduced gp91^phox-positive reactive microglia at this time point. Bar = 25 μm.