Figure 6

Unbiased stereological quantification of hippocampal neurons at four months post-injury. CHPG-treatment resulted in significantly reduced TBI-induced total neuron (Ai) loss in the hippocampus when compared to vehicle-treated samples. In addition, CHPG-treatment significantly spared neurons in the CA3 (Aiii) and dentate gyrus (Aiv) sub-subfields of the hippocampus (*P < 0.05, ***P < 0.001 versus vehicle; n = 3). In contrast, co-administration of MTEP with CHPG reversed the neuroprotective effects of CHPG-treatment in each hippocampal sub-field (+P < 0.05 versus CHPG). Statistical analysis was by one-way ANOVA with Student-Newman-Keuls post-hoc corrections. Bars represent mean ± SEM.