Administration of anti-TLR4 monoclonal antibody immediately after ICH provided neuroprotection. Administration of antibody against TLR4 in WT mice of ICH decreased brain water content (A) and NDS (B). Administration of antibody against TLR4 in WT mice significantly decreased cytokine release (C) and macrophage infiltration (D) in response to ICH. **P < 0.01 vs. WT group. Scale bar = 50 μM (D). Values (mean ± SD, n = 6 for each group) are representative of three independent experiments.