Figure 3
The effect of long-term acetate supplementation on brain histone deacetylase and histone acetyltransferase activities in control rats (aCSF), rats subjected to neuroinflammation (LPS) and rats treated with either water (H 2 O) or glyceryl triacetate (GTA). (A) Represents changes in brain HAT, and (B) represents changes in HDAC activities. HAT enzyme activity is expressed as the means ± SD of absorbance reading at 450 nm after 4 hours of incubation at 37°C, normalized to the protein assayed (μg). HDAC enzyme activity is expressed as the means ± SD of absorbance at 405 nm after 75 minutes of incubation at 37°C, normalized to the protein assayed (μg). Statistical significance (*compared to aCSF + H2O controls) was set at P ≤ 0.05, as determined by nonparametric one-way ANOVA followed by Dunn's post-hoc test.