Figure 3

ADAMTS-4 restores neurite outgrowth. P8 rat cerebellar granular neurons were cultured on PLL (A) or PG extracted from chick brains (B). ADAMTS-4 (C) and C-ABC (D) treatments restored the neurite outgrowth. Scale bar, 200 μm. (E) The quantification of A to D. Data represent the relative ratio of the average neurite length ± SD comparing PLL. *, P < 0.01 (versus PG: repeated-measures ANOVA). ANOVA, analysis of variance; C-ABC, chondroitinase ABC; PG, proteoglycan; PLL, poly-L-lysine.