in spleen is required for the acceleration of prion disease by experimental autoimmune encephalomyelitis. (A) Brain and spleen samples from scrapie-infected mice (C57Bl/6 J, RML strain) at several incubation points (1 week, 1 month, sick) were tested for the levels of proteinase K digested PrPSc. (B) Prion-infected mice were induced for MOG-EAE one week (n = 5) and one month (n = 6) after prion infection and followed for signs of disease. The clinical scores of the group induced with EAE one month post infection were significantly different (P = 0.025) as compared to naïve mice induced for EAE (n = 6). The clinical scores of mice with EAE induced one week post infection were not statistically different (P = 0.5) as compared to naïve mice induced for EAE (n = 6). (C) Table presenting chronological symptoms of the scrapie-EAE syndrome. (D) Survival curves of mice from the designated groups. Scrapie/EAE at one month was statistically different (P = 0.0033) as compared to the corresponding scrapie/EAE at one week.