Figure 1
From: Targeting of prion-infected lymphoid cells to the central nervous system accelerates prion infection
PrP Sc in spleen is required for the acceleration of prion disease by experimental autoimmune encephalomyelitis. (A) Brain and spleen samples from scrapie-infected mice (C57Bl/6 J, RML strain) at several incubation points (1 week, 1 month, sick) were tested for the levels of proteinase K digested PrPSc. (B) Prion-infected mice were induced for MOG-EAE one week (n = 5) and one month (n = 6) after prion infection and followed for signs of disease. The clinical scores of the group induced with EAE one month post infection were significantly different (P = 0.025) as compared to naïve mice induced for EAE (n = 6). The clinical scores of mice with EAE induced one week post infection were not statistically different (P = 0.5) as compared to naïve mice induced for EAE (n = 6). (C) Table presenting chronological symptoms of the scrapie-EAE syndrome. (D) Survival curves of mice from the designated groups. Scrapie/EAE at one month was statistically different (P = 0.0033) as compared to the corresponding scrapie/EAE at one week.