Figure 3

Transmission electron micrographs of the retina. Left upper panel: the retina of the untreated eye shows degeneration of RPE and photoreceptors. The photoreceptors are dystrophic with many dislocated nuclei (asterisk) and loss of both inner and outer segments. Left lower panel: the RPE cell contains lipofuscin-like liposomal inclusions (arrows) and decreased basal infoldings (asterisk). Bruch's membrane shows electron dense debris (blue arrows). Right upper panel: the ultrastructure of the retina from a treated eye is intact with well-preserved photoreceptors including healthy inner (IS) and outer (OS) segments and RPE cells. Right lower panel: the RPE cell contains many normal mitochondria (arrows) and basal infoldings (asterisk).