Figure 4
Increased vascular permeability in the brains of C57BL/6 compared to 129 SvIm mice following induction of peptide-induced fatal syndrome. Intravenously administered fluorescein isothiocyanate (FITC)-albumin is detectable in homogenized brains of C57BL/6 mice 24 hours after administration of VP2121-130, but not E7 peptide. VP2121-130 peptide-treated 129 SvIm mice have detectable FITC-albumin leakage compared to E7 peptide-treated controls. C57BL/6 mice have significantly higher levels of detectable FITC-albumin in the forebrain than 129 SvIm mice 24 hours after induction of peptide-induced fatal syndrome. Asterisks denote statistical significance (P < 0.05). Each group consisted of six mice. One VP2121-130 peptide-treated C57BL/6 mouse had to be killed and was removed from the study.