Figure 7
A hematopoietic factor contributes to enhanced astrocyte glial fibrillary acidic protein expression. Irradiated 129 Svlm mice were reconstituted with either autologous 129 Svlm bone marrow (n = 12) or C57BL/6 bone marrow (n = 5). Both groups were intravenously administered VP2121-130 peptide 7 days post-Theiler's murine encephalomyelitis virus infection. 129 Svlm mice reconstituted with C57BL/6 bone marrow displayed a significant increase in glial fibrillary acidic protein expression in brain lysates compared to 129 Svlm mice that received syngeneic bone marrow transfer (P < 0.001).