Figure 9

129 Svlm mice reconstituted with C57BL/6 bone marrow display an increase in central nervous system vascular permeability as measured by gadolinium-enhanced T1-weighted MRI scans 24 hours post-VP2 _121-130 peptide administration to induce peptide-induced fatal syndrome. The extent of central nervous system vascular permeability is shown by three-dimensional transparency rendering of gadolinium-enhancing areas in (A) 129 Svlm mice reconstituted with autologous 129 Svlm bone marrow (n = 5) or in (B) 129 Svlm mice reconstituted with C57BL/6 bone marrow (n = 5). Red areas indicate subvolumes with gadolinium enhancement. The overall thickness of underlying gadolinium enhancement and the distance from the surface influence the intensity of these areas. (C) Quantification of the three-dimensional volume of vascular permeability in each group. 129 Svlm mice reconstituted with C57BL/6 bone marrow exhibit a significant increase in vascular permeability compared to 129 Svlm mice reconstituted with autologous 129 Svlm bone marrow (P < 0.001).