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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury

Figure 3

Trichostatin A (TSA) persistently increases histone acetylation at 24 hours after injury. (A) Western blots of acetylated histone-4(Ac-H4), acetylated histone-3 (Ac-H3, molecular weight 17 kDa) and reference protein H2B in female lipopolysaccharide-sensitised hypoxiaischaemia (LPS/HI) mice (red bars) and LPS + TSA/HI mice (green bars) 24 hours after injury. (B) and (C) Mean normalised acetylation data are shown for Ac-H4 (B) and Ac-H3 (C) (all n = 7). Data are means ± SEM. *P<0.05 treatment effect by one-way ANOVA, #P<0.05 by post hoc t-test.

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Journal of Neuroinflammation

ISSN: 1742-2094