Figure 1
From: The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation
PrP106-126 induces the release of interleukin (IL)-1β. Cells were primed with 300 ng/ml lipopolysaccharide (LPS) for 3 hours, and then left untreated or stimulated with PrP106-126 (100 μmol/l) or Scr (100 μmol/l). Data show ELISA analysis of the release of IL-1β by (a) mouse primary microglia and (b) BV2 cell lines. Data represent the mean ± SD of triplicate samples from one of three independent experiments. *P < 0.05, significantly different from control and Scr-treated cells under the same experimental conditions.