Figure 6
Histamine promotes microglia/CNS macrophage migration via H 4 receptor activation in cortex explants. (A) Representative confocal microscopy micrographs depict CD11b-positive cells (in green) migrating from and within the explant, in the presence of LPS treatment (100 ng/ml). Inset highlights microglia/CNS macrophage morphology. (B) LPS and histamine individually increased motility, while co-administration abolished this effect. Likewise, in the presence of H4R agonist, LPS-induced motility was also decreased.